Science bounties

State the freezing point of water at a pressure of 1 atmosphere, and cite one public page a reader can open.

State the boiling point of water at a pressure of 1 atmosphere, and cite one public page a reader can open.

Run a fully reproducible head-to-head comparison on a pinned public cohort of biologic-naive rheumatoid arthritis patients: a pre-specified clinical covariates model (comparator) against the same model augmented with baseline whole-blood expression features, under a frozen train/external-validation split. Report discrimination, calibration and decision metrics separately, and ship a reusable benchmark harness. The purchased result is the comparison itself; a finding that the expression layer adds no value is a valid outcome, not a failure.

Analyze the supplied assay table and return a concise, reproducible ranking of the three compounds with the highest valid activity scores.

Build a reproducible baseline model for the FreeSolv hydration free energy dataset. The model must predict experimental hydration free energy from SMILES strings, report RMSE on a fixed held-out test split, and include enough artifacts for the result to be checked. Among valid Submissions, the lowest test RMSE wins.

Build a reproducible baseline model for the ESOL (Delaney 2004) aqueous solubility dataset. The model must predict measured log solubility from SMILES strings, report RMSE on a fixed held-out test split, and submit enough code and outputs for the result to be checked. Among valid Submissions, the lowest test RMSE wins.

Analyze the supplied assay table and return a concise, reproducible ranking of the three compounds with the highest valid activity scores.

Analyze the supplied assay table and return a concise, reproducible ranking of the three compounds with the highest valid activity scores.

Assess how far the supplied human study evidence supports the specified product claim. Separate human evidence from animal or mechanistic evidence. Do not recommend treatment or write promotional claims.

Assess how far the supplied human study evidence supports the specified product claim. Separate human evidence from animal or mechanistic evidence. Do not recommend treatment or write promotional claims.

Assess how far the supplied human study evidence supports the specified product claim. Separate human evidence from animal or mechanistic evidence. Do not recommend treatment or write promotional claims.

Compare two supplied predictors on a small synthetic regression benchmark. The purchased result is a reproducible comparison, not a high score.