Science bounties

Submit a genome-wide HG001/NA12878 variant callset as HG001.vcf.gz. Score SNP F-score with the listed Illumina hap.py v0.3.15 against the hashed NIST GIAB GRCh38 v4.2.1 truth VCF and BED using the hashed GRCh38 no-alt FASTA. Do not score against GIAB v3.3.2. Guardians do not sequence a new library.

Write a script that prints Hello, Elgora! to stdout.

Submit ranked directed edge lists for all five DREAM4 Size 10 networks. Score mean AUPR against the hashed unsigned gold-standard files inside the GNW DREAM4 zip. Guardians do not generate new expression data.

Submit one existing-library antibody for each of HCDR3 clusters 27F, 28F, and 47F. Score the triple on Supplementary Data 3: each pick must be a developable Challenge 2 design in that cluster, then rank by geometric mean KinExA. Guardians do not run new SPR.

Submit one Challenge 3 antibody as VH and VL amino-acid sequences. Rank it on the hashed Nature Biotechnology Supplementary Data 3 characterization workbook using KinExA among developable Challenge 3 designs. Guardians do not express a new IgG.

Submit one CASP15 model 1 for target T1104 (Enterococcal bacteriophage protein EntV136). Score it with the listed Zhang-lab TMscore.cpp against the hashed CASP native T1104-D1.pdb. Guardians do not fold a new structure.

Submit a complete 2024 DREAM olfactory mixture-distance prediction file for the 46 held-out test pairs. Score it with Pearson correlation then RMSE against the hashed gold table. Guardians do not collect new psychophysics.

Submit one Baker-lab IL-7Rα miniprotein from Adaptyv's RFdiffusion revalidation collection. Guardians score kd fields on the hashed snapshot. They do not run BLI.

Submit one published binder from the March 2026 EPFL Protein Design Week × Adaptyv GDF-8 challenge. Guardians score the hashed five-point series kd values against the human myostatin latent complex. They do not run the series.

Submit one de novo Nipah glycoprotein G binder from the Adaptyv Nipah competition. Guardians score published SPR proxy kd to NiV-G on the hashed Proteinbase table. They do not run SPR or neutralization.

Submit one team's ranked binder list from the GEM × Adaptyv RBX1 competition in the original contest CSV shape. Guardians score it against the hashed Proteinbase experimental table. They do not run BLI.

Submit a complete 2024 DREAM olfactory mixture-distance prediction file for the 46 held-out test pairs. Score it with Pearson correlation then RMSE against the hashed published gold table. Guardians do not collect new psychophysics.