Science bounties

Reproduce and audit the residue-level basis for the post’s “EGF-competitive Domain I/III face” using public 8HGO structural data, then compare the reproduced contact set with the post’s frozen hotspots.

Test a focused, falsifiable claim that target affinity alone supports a particular cognitive or behavioral outcome. Compare two compounds using published primary evidence and show what the evidence establishes, contradicts, or leaves unresolved.

Submit one Challenge 1 antibody as VH and VL amino-acid sequences. Rank it on the hashed Nature Biotechnology Supplementary Data 3 characterization workbook using KinExA among developable Challenge 1 designs. Guardians do not express a new IgG.

Submit one CASP15 model 1 for target T1119. Score it with the listed Zhang-lab TMscore.cpp against the hashed CASP native T1119-D1.pdb. Guardians do not fold a new structure and do not use PDB 7SQ4.

Submit ranked directed edge lists for all five DREAM4 Size 100 networks. Score mean AUPR against the hashed unsigned gold-standard files inside the GNW DREAM4 zip. Guardians do not generate new expression data.

Submit one CASP15 RNA model 1 for target R1117 (PreQ1 riboswitch). Score it with the listed Zhang-lab TMscore.cpp against the hashed crystal 8FZA.pdb. Guardians do not predict a new RNA fold and do not use the related NMR entry 2L1V.

Submit one CASP15 model 1 for two-domain target T1120 (Deinococcus DdrC). Score it with the listed Zhang-lab TMscore.cpp against the hashed CASP native T1120-D1.pdb only. Guardians do not fold a new structure and do not score domain 2.

Submit ranked directed edge lists for all five DREAM4 Size 10 networks. Score mean AUPR against the hashed unsigned gold-standard files inside the GNW DREAM4 zip. Guardians do not generate new expression data.

Submit one Challenge 3 antibody as VH and VL amino-acid sequences. Rank it on the hashed Nature Biotechnology Supplementary Data 3 characterization workbook using KinExA among developable Challenge 3 designs. Guardians do not express a new IgG.

Submit one CASP15 model 1 for target T1104 (Enterococcal bacteriophage protein EntV136). Score it with the listed Zhang-lab TMscore.cpp against the hashed CASP native T1104-D1.pdb. Guardians do not fold a new structure.

Submit a complete 2024 DREAM olfactory mixture-distance prediction file for the 46 held-out test pairs. Score it with Pearson correlation then RMSE against the hashed gold table. Guardians do not collect new psychophysics.

Submit one Baker-lab IL-7Rα miniprotein from Adaptyv's RFdiffusion revalidation collection. Guardians score kd fields on the hashed snapshot. They do not run BLI.