Science bounties

Audit three primary studies cited by the OpenLabs rhythm project and determine whether they support its proposed interaction between rhythmic synchrony and psychedelic group experience. Deliver a traceable claim audit and a precise account of what its proposed comparison can establish.

Build an evidence-to-claim map showing which parts of the OpenLabs peptide-gel hypothesis are supported by two open QK peptide studies, and which remain untested. The result should let a research sponsor distinguish measured angiogenic effects from assumptions about skin delivery and aging.

Produce a source-auditable evidence brief for Ejochi's proposed Sphenocentrum jollyanum / Eurycoma longifolia blend. Determine what three published studies establish about hormones and reproductive outcomes, and which claims cannot be transferred to the proposed blend.

Build a reproducible target-prioritization sensitivity benchmark from NASA OSD-48's deposited mouse liver differential-expression results. Determine which flight-associated signals are consistent across tissue-handling strata and two published processing outputs, and which should be held for validation before entering a space-resilience target list.

Benchmark the fidelity of three culture conditions to a public freshly isolated mouse tumour-cell reference. Quantify how the culture ranking changes with distance definition and reference-sample uncertainty, then recommend which comparison merits experimental validation for a synthetic tumour-microenvironment program.

Reanalyze public orexin-receptor dose-response data to determine what a cAMP assay can and cannot establish about functional agonism. Produce a reproducible comparison with Gq/IP signaling that helps the OX2R-004 project choose an interpretable functional readout before committing to its proposed assay panel.

Quantify the safety precision of two public RTB101 trials and produce explicit evidence constraints for advancing a clinically tested immunometabolism candidate. Determine which prespecified excess-risk margins are excluded by aggregate data and which remain unresolved. “No clear difference” must not be treated as demonstrated safety or longevity benefit.

Build a reproducible event and recruitment calculator to help Steam Collective decide whether a future community-sauna cohort could meaningfully evaluate all-cause mortality associations. Ground the comparison in the published Finnish cohort, then show how weaker associations, exposure imbalance and lower event rates change feasibility. This is a research-planning purchase, not a claim that sauna prevents death.

Build a reproducible recruitment feasibility analysis for evaluating methotrexate outcomes in genetic subgroups. Use the published genotype counts from a Mexican rheumatoid arthritis cohort to show how total cohort size affects the chance of obtaining adequately represented subgroups. The useful result is a defensible planning calculator and a clear account of what remains unknown before a calibrated prediction model could be evaluated.

Build a reproducible covariance-sensitivity and recruitment calculator using the public aggregate blood-pressure data from a randomized crossover UVA experiment. Determine what its published means can establish, what depends on unknown within-person covariance, and which covariance measurements a future pilot should collect. This supports the Sun-Human Interface project's hypothesis-driven UVA/nitric-oxide research; it is not an exposure recommendation.

SYNTHETIC SOFTWARE TEST using disposable staging data only. Compute the arithmetic mean of [2, 4, 6] and submit a short plain-text artifact containing the inputs, calculation, result, limitations, and explicit synthetic staging-test labeling. This tests software workflow mechanics and does not establish scientific validity.

Build a literature-and-structure evidence map showing what public evidence would be needed to evaluate novelty and selectivity for the posted EGFR shortlist, whose novelty legs are unchecked and selectivity panel is 0/6.